The effect of gut microbiota on the severity of COVID-19
illness COVID-19 It attacks not only the tissues of the respiratory system, but also the composition of the intestinal microflora (intestinal microbiota), which affects the severity of the course of the disease. The consequences persisted long after the virus infection was overcome.
In a new study, experts from Campinas State University Investigate the functional role of the gut microbiota in the long-term consequences of COVID-19. The results are published on a prepress server in English”search fieldChest.
Effects of COVID-19 on gut health
After you contract COVID-19, long term consequences which have a significant impact on the lives of those affected. Here the question arose about whether there is a connection with Changes in the gut microbiota The researchers explain.
In their investigations, experts have now found that the intestinal microbiota after infection with COVID-19 (up to four months after the first positive test) shows a marked dominance of the so-called Intestinal bacteria strains with a multi-resistant phenotype Shown compared to healthy people from the control group.
Increased pneumonia caused by gut microbes
After the team transferred feces from the participants into germ-free mice, the animals given samples from COVID-19 patients showed More severe pneumonia and one more Increased susceptibility to lung infectionsDue to a resistant strain of Klebsiella pneumoniae.
Cognitive performance decreased
These mice also showed one poor cognitive performanceWhich has been linked to increased expression of TNF-α, experts said, with decreased levels of something called neurotrophic factor BDNF and postsynaptic density protein PSD-95 in the brain. In addition, it also happened Changes in different biochemical signaling pathways on me.
These changes are observed in the absence of SARS-CoV-2, so according to the researchers Changes in the gut microbiota Scheduled. The study also showed that the effects of SARS-CoV-2 infection on the intestinal microbiota persist even after long-term patients have overcome the acute viral infection.
Healthy Bacteria Prevent Brain Weakness
Functional disorders of the brain, which were found in the mouse MERS-CoV infection model, can be partially corrected by germ modification By treatment with Probiotic Bifidobacterium longum 51A Prevention, team reports.
Overall, the results of the new research confirm that The importance of germs as a target for treatments Treating the so-called after-effects of COVID, summarized the experts. (as such)
Author and source information
This text conforms to specifications in the medical literature, clinical guidelines and current studies and has been examined by medical professionals.
- Viviani Mendes de Almeida, Daiane F. Engel, Mayra Fernanda Ricci, Clênio Silva Cruz, Icaro Santos Lopes, et al: Intestinal microbiota from mild COVID-19 patients causes changes in mice resembling post-COVID syndrome. In: Research Square (published on 06/22/2022), search field
This article contains general advice only and should not be used for self-diagnosis or treatment. It cannot replace a visit to the doctor.
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